3',4'-Methylenedioxy-α-pyrrolidinopropiophenone
Chemical compound
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By mouth , insufflation, Vaporization, IV, rectal, sublingual |
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Metabolism | Hepatic |
Excretion | Primarily Urine (Renal) |
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Formula | C 14 H 17 N O 3 |
Molar mass | 247.294 g·mol −1 |
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Chirality | Racemic mixture |
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3',4'-Methylenedioxy-α-pyrrolidinopropiophenone ( MDPPP ) is a stimulant designer drug . It was sold in Germany in the late 1990s and early 2000s as an ingredient in imitation ecstasy (MDMA) pills. [1] It shares a similar chemical structure with α-PPP and MDPV , [2] [3] [4] and has been shown to have reinforcing effects in rats. [5]
Metabolism
MDPPP appears to have a similar metabolic fate as MDPV . [4]
Legal Status
As of October 2015 [ update ] MDPPP is a controlled substance in China. [6]
See also
References
- ↑ Springer D, Fritschi G, Maurer HH (August 2003). "Metabolism and toxicological detection of the new designer drug 3',4'-methylenedioxy-alpha-pyrrolidinopropiophenone studied in urine using gas chromatography-mass spectrometry". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences . 793 (2): 377–88. doi : 10.1016/S1570-0232(03)00350-7 . PMID 12906913 .
- ↑ Maurer HH, Kraemer T, Springer D, Staack RF (April 2004). "Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis". Therapeutic Drug Monitoring . 26 (2): 127–31. doi : 10.1097/00007691-200404000-00007 . PMID 15228152 . S2CID 9255084 .
- ↑ Staack RF, Maurer HH (June 2005). "Metabolism of designer drugs of abuse". Current Drug Metabolism . 6 (3): 259–74. doi : 10.2174/1389200054021825 . PMID 15975043 .
- 1 2 Springer D, Staack RF, Paul LD, Kraemer T, Maurer HH (March 2005). "Identification of cytochrome P450 enzymes involved in the metabolism of 3',4'-methylenedioxy-alpha-pyrrolidinopropiophenone (MDPPP), a designer drug, in human liver microsomes". Xenobiotica; the Fate of Foreign Compounds in Biological Systems . 35 (3): 227–37. doi : 10.1080/00498250400028239 . PMID 16019948 . S2CID 28207896 .
- ↑ Gannon BM, Galindo KI, Mesmin MP, Sulima A, Rice KC, Collins GT (May 2018). "Relative reinforcing effects of second-generation synthetic cathinones: Acquisition of self-administration and fixed ratio dose-response curves in rats" . Neuropharmacology . 134 (Pt A): 28–35. doi : 10.1016/j.neuropharm.2017.08.018 . PMC 5809320 . PMID 28811192 .
- ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015 . Retrieved 1 October 2015 .
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