Formetorex
Chemical compound
Names | |
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Preferred IUPAC name
N
-(1-Phenylpropan-2-yl)formamide
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Other names
Formetorex
N -Formylamphetamine N -( alpha -Methylphenethyl)formamide |
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Identifiers | |
3D model (
JSmol
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1563 | |
ChEMBL | |
ChemSpider | |
PubChem
CID
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UNII | |
CompTox Dashboard
(
EPA
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Properties | |
C 10 H 13 N O | |
Molar mass | 163.220 g·mol −1 |
Except where otherwise noted, data are given for materials in their
standard state
(at 25
°C [77
°F], 100
kPa).
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Formetorex ( INN ), also known as formetamide or N -formylamphetamine , is a substituted amphetamine described as an anorectic which does not appear to have ever been marketed. [1]
Formetorex is also an intermediate in the production of amphetamine by the " Leuckart reaction ." [2] It is also commonly found as an impurity in clandestine labs where this synthesis method is used. [2] [3] Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines. [2] The synthesis involves a non-metal reduction that is typically carried out in three steps. [2] For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid ) or ammonium formate , is heated until a condensation reaction results in the intermediate product, formetamide. [2] In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base. [2] The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid. [2]
References
- ↑ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents . CRC Press. pp. 568–. ISBN 978-0-412-46630-4 .
- 1 2 3 4 5 6 7 Laboratory and Scientific Section (2006). Recommended methods of the identification and analysis of amphetamine, methamphetamine, and their ring-substituted analogues in seized materials (PDF) . New York: United Nations Office on Drugs and Crime Vienna. ISBN 92-1-148208-9 . Retrieved 14 October 2013 .
- ↑ Kram TC (July 1979). "Reidentification of a major impurity in illicit amphetamine". Journal of Forensic Sciences . 24 (3): 596–9. doi : 10.1520/JFS10875J . PMID 541629 .
External links
- formetamide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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Phenethylamines |
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Phenylalkylpyrrolidines | |
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