6-Fluoronorepinephrine
Chemical compound
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Formula | C 8 H 10 F N O 3 |
Molar mass | 187.170 g·mol −1 |
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6-Fluoronorepinephrine ( 6-FNE ) is a selective α 1 - and α 2 -adrenergic receptor full agonist related to norepinephrine . [1] [2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research. [2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α 1 -adrenergic receptors. [2] [3]
References
- ↑ Kirk KL, Cantacuzene D, Nimitkitpaisan Y, McCulloh D, Padgett WL, Daly JW, Creveling CR (1979). "Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines". Journal of Medicinal Chemistry . 22 (12): 1493–7. doi : 10.1021/jm00198a012 . PMID 231654 .
- 1 2 3 Stone EA, Lin Y, Sarfraz Y, Quartermain D (2009). "Marked behavioral activation from inhibitory stimulation of locus coeruleus α 1 -adrenoceptors by a full agonist" . Brain Research . 1291 : 21–31. doi : 10.1016/j.brainres.2009.07.049 . PMC 2735576 . PMID 19632210 .
- ↑ Stone EA, Grunewald GL, Lin Y, Ahsan R, Rosengarten H, Kramer HK, Quartermain D (2003). "Role of epinephrine stimulation of CNS α 1 -adrenoceptors in motor activity in mice". Synapse . 49 (1): 67–76. doi : 10.1002/syn.10212 . PMID 12710017 . S2CID 35324292 .
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