GBR-13098
Chemical compound
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Names | |
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IUPAC name
1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-[3-(4-fluorophenyl)propyl]piperazine;methanesulfonic acid
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Identifiers | |
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3D model (
JSmol
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ChEMBL |
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ChemSpider | |
PubChem
CID
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Properties | |
C 30 H 39 F 3 N 2 O 7 S 2 | |
Molar mass | 660.76 g·mol −1 |
Except where otherwise noted, data are given for materials in their
standard state
(at 25
°C [77
°F], 100
kPa).
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GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor . [1]
Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevent damage to the DA nerve terminals caused by malonate . It was suggested that DA transporter inhibitors like GBR-13098 could be used to prevent or treat neurodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis. [2]
See also
References
- ↑ Pileblad E, and Engberg G. (Dec 1986). "GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies". Naunyn Schmiedebergs Arch Pharmacol . 334 (4): 383–7. doi : 10.1007/BF00569374 . PMID 2950328 . S2CID 4685374 .
- ↑ Moy LY; et al. (Feb 2007). "Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter". J Pharmacol Exp Ther . 320 (2): 747–56. doi : 10.1124/jpet.106.110791 . PMID 17090704 . S2CID 9886591 .
Simple piperazines
(no additional rings) |
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Phenylpiperazines |
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Benzylpiperazines | |
Diphenylalkylpiperazines
(benzhydrylalkylpiperazines) |
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Pyrimidinylpiperazines | |
Pyridinylpiperazines | |
Benzo(iso)thiazolyl piperazines | |
Tricyclics
(piperazine attached via side chain) |
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Others/Uncategorized |
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