Fezolamine
Chemical compound
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Formula | C 20 H 23 N 3 |
Molar mass | 305.425 g·mol −1 |
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Fezolamine ( Win-41,528-2 ) is a drug which was investigated by Sterling Drug as an antidepressant in the 1980s. [1] [2] The isomeric N , N -dimethyl-4,5-diphenyl-1 H -pyrazole-1-propanamine was completely inactive in the primary antidepressant screens.
It acts as a serotonin , norepinephrine , and dopamine reuptake inhibitor , with 3- to 4-fold preference for the former neurotransmitter . [3] It was found to be effective and well tolerated in clinical trials but was never marketed. [4]
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References
- ↑ U.S. Patent 4,182,895
- ↑ Bailey DM, Hansen PE, Hlavac AG, Baizman ER, Pearl J, DeFelice AF, Feigenson ME (February 1985). "3,4-Diphenyl-1H-pyrazole-1-propanamine antidepressants". Journal of Medicinal Chemistry . 28 (2): 256–60. doi : 10.1021/jm00380a020 . PMID 3968690 .
- ↑ Baizman ER, Ezrin AM, Ferrari RA, Luttinger D (October 1987). "Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models". The Journal of Pharmacology and Experimental Therapeutics . 243 (1): 40–54. PMID 3668867 .
- ↑ Zisook S, Mendels J, Janowsky D, Feighner J, Lee JC, Fritz A (1987). "Efficacy and safety of fezolamine in depressed patients". Neuropsychobiology . 17 (3): 133–8. doi : 10.1159/000118353 . PMID 3683802 .
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