JZ-IV-10
Chemical compound
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Formula | C 18 H 27 Cl N 2 O S |
Molar mass | 354.94 g·mol −1 |
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JZ-IV-10 is a piperidine derivative related to cocaine which acts as a highly potent serotonin–norepinephrine–dopamine reuptake inhibitor (also called SNDRI, or triple reuptake inhibitor). [1] The eugeroic modafinil was used as a lead to fuel this compound's discovery. [2] [3]
See also
References
- ↑ WO 2005041875 , Kozikowski, Alan P. & Zhou, Jia, "Dopamine-, norepinephrine- and serotonin- transporter- selective heterocyclic compounds and their therapeutic applications", published 2005-05-12, assigned to Georgetown University
- ↑ Zhou J, He R, Johnson KM, Ye Y, Kozikowski AP (November 2004). "Piperidine-based nocaine/modafinil hybrid ligands as highly potent monoamine transporter inhibitors: efficient drug discovery by rational lead hybridization" . Journal of Medicinal Chemistry . 47 (24): 5821–4. doi : 10.1021/jm040117o . PMC 1395211 . PMID 15537337 .
- ↑ He R, Kurome T, Giberson KM, Johnson KM, Kozikowski AP (December 2005). "Further structure-activity relationship studies of piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands and broad-spectrum transporter inhibitors". Journal of Medicinal Chemistry . 48 (25): 7970–9. doi : 10.1021/jm050694s . PMID 16335921 .
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