Isometheptene
Sympathomimetic amine
Clinical data | |
---|---|
AHFS / Drugs.com | International Drug Names |
MedlinePlus | a601064 |
Routes of
administration |
Oral |
ATC code | |
Identifiers | |
|
|
CAS Number |
|
PubChem CID | |
DrugBank |
|
ChemSpider |
|
UNII | |
CompTox Dashboard ( EPA ) | |
ECHA InfoCard | 100.007.236 |
Chemical and physical data | |
Formula | C 9 H 19 N |
Molar mass | 141.258 g·mol −1 |
3D model ( JSmol ) | |
|
|
|
|
(verify) |
Isometheptene (usually as isometheptene mucate ) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties; that is, it causes constriction (narrowing) of blood vessels ( arteries and veins ). [1] [2] Along with paracetamol and dichloralphenazone , it is one of the constituents of Amidrine .
Chemistry
Isometheptene is a monounsaturated aliphatic secondary amine .
Mechanism of action
Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine . These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors. [3]
See also
References
- ↑ Diamond S, Medina JL (October 1975). "Isometheptene--a non-ergot drug in the treatment of migraine". Headache . 15 (3): 211–3. doi : 10.1111/j.1526-4610.1975.hed1503211.x . PMID 1100566 . S2CID 34768775 .
- ↑ Behan PO (December 1978). "Isometheptene compound in the treatment of vascular headache". The Practitioner . 221 (1326): 937–9. PMID 372936 .
- ↑ "Isometheptene" . Drug Bank .
Drugs for
functional gastrointestinal disorders
(
A03
)
|
|||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Drugs for
functional bowel disorders |
|
||||||||||||
Belladonna
and derivatives ( antimuscarinics ) |
|
||||||||||||
Propulsives |
DRAs |
|
|||||||
---|---|---|---|---|---|---|---|---|
NRAs |
|
|||||||
SRAs |
|
|||||||
Others |
|
|||||||