Fallypride
Chemical compound
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Formula | C 20 H 29 F N 2 O 3 |
Molar mass | 364.461 g·mol −1 |
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Fallypride is a high affinity dopamine D2/D3 receptor antagonist used in medical research, [1] usually in the form of fallypride ( 18 F ) as a positron emission tomography (PET) radiotracer in human studies. [2] [3]
References
- ↑ Mukherjee J, Yang ZY, Das MK, Brown T (April 1995). "Fluorinated benzamide neuroleptics--III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer". Nuclear Medicine and Biology . 22 (3): 283–96. doi : 10.1016/0969-8051(94)00117-3 . PMID 7627142 .
- ↑ Mukherjee J, Christian BT, Dunigan KA, Shi B, Narayanan TK, Satter M, Mantil J (December 2002). "Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors". Synapse . 46 (3): 170–88. doi : 10.1002/syn.10128 . PMID 12325044 . S2CID 24852944 .
- ↑ Rieck RW, Ansari MS, Whetsell WO, Deutch AY, Kessler RM (February 2004). "Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies" . Neuropsychopharmacology . 29 (2): 362–72. doi : 10.1038/sj.npp.1300336 . PMID 14627996 .
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