5-HT
1
|
5-HT
1A
|
-
Agonists:
8-OH-DPAT
-
Adatanserin
-
Amphetamine
-
Antidepressants
(e.g.,
etoperidone
,
hydroxynefazodone
,
nefazodone
,
trazodone
,
triazoledione
,
vilazodone
,
vortioxetine
)
-
Atypical antipsychotics
(e.g.,
aripiprazole
,
asenapine
,
brexpiprazole
,
cariprazine
,
clozapine
,
lurasidone
,
quetiapine
,
ziprasidone
)
-
Azapirones
(e.g.,
buspirone
,
eptapirone
,
gepirone
,
perospirone
,
tandospirone
)
-
Bay R 1531
-
Befiradol
-
BMY-14802
-
Cannabidiol
-
Dimemebfe
-
Dopamine
-
Ebalzotan
-
Eltoprazine
-
Enciprazine
-
Ergolines
(e.g.,
bromocriptine
,
cabergoline
,
dihydroergotamine
,
ergotamine
,
lisuride
,
LSD
,
methylergometrine (methylergonovine)
,
methysergide
,
pergolide
)
-
F-11,461
-
F-12826
-
F-13714
-
F-14679
-
F-15063
-
F-15,599
-
Flesinoxan
-
Flibanserin
-
Flumexadol
-
Hypidone
-
Lesopitron
-
LY-293284
-
LY-301317
-
mCPP
-
MKC-242
-
Naluzotan
-
NBUMP
-
Osemozotan
-
Oxaflozane
-
Pardoprunox
-
Piclozotan
-
Rauwolscine
-
Repinotan
-
Roxindole
-
RU-24,969
-
S-14,506
-
S-14671
-
S-15535
-
Sarizotan
-
Serotonin (5-HT)
-
SSR-181507
-
Sunepitron
-
Tryptamines
(e.g.,
5-CT
,
5-MeO-DMT
,
5-MT
,
bufotenin
,
DMT
,
indorenate
,
N-Me-5-HT
,
psilocin
,
psilocybin
)
-
TGBA01AD
-
U-92,016-A
-
Urapidil
-
Vilazodone
-
Xaliproden
-
Yohimbine
|
-
Antagonists:
Atypical antipsychotics
(e.g.,
iloperidone
,
risperidone
,
sertindole
)
-
AV965
-
Beta blockers
(e.g.,
alprenolol
,
carteolol
,
cyanopindolol
,
iodocyanopindolol
,
isamoltane
,
oxprenolol
,
penbutolol
,
pindobind
,
pindolol
,
propranolol
,
tertatolol
)
-
BMY-7,378
-
CSP-2503
-
Dotarizine
-
Ergolines
(e.g.,
metergoline
)
-
FCE-24379
-
Flopropione
-
GR-46611
-
Isamoltane
-
Lecozotan
-
Mefway
-
Metitepine (methiothepin)
-
MIN-117 (WF-516)
-
MPPF
-
NAN-190
-
Robalzotan
-
S-15535
-
SB-649,915
-
SDZ 216-525
-
Spiperone
-
Spiramide
-
Spiroxatrine
-
UH-301
-
WAY-100135
-
WAY-100635
-
Xylamidine
|
|
|
5-HT
1B
|
-
Agonists:
Anpirtoline
-
CGS-12066A
-
CP-93129
-
CP-94253
-
CP-122,288
-
CP-135807
-
Eltoprazine
-
Ergolines
(e.g.,
bromocriptine
,
dihydroergotamine
,
ergotamine
,
methylergometrine (methylergonovine)
,
methysergide
,
pergolide
)
-
mCPP
-
RU-24,969
-
Serotonin (5-HT)
-
Triptans
(e.g.,
avitriptan
,
donitriptan
,
eletriptan
,
sumatriptan
,
zolmitriptan
)
-
TFMPP
-
Tryptamines
(e.g.,
5-BT
,
5-CT
,
5-MT
,
DMT
)
-
Vortioxetine
|
|
|
|
5-HT
1D
|
-
Agonists:
CP-122,288
-
CP-135807
-
CP-286601
-
Ergolines
(e.g.,
bromocriptine
,
cabergoline
,
dihydroergotamine
,
ergotamine
,
LSD
,
methysergide
)
-
GR-46611
-
L-694247
-
L-772405
-
mCPP
-
PNU-109291
-
PNU-142633
-
Serotonin (5-HT)
-
TGBA01AD
-
Triptans
(e.g.,
almotriptan
,
avitriptan
,
donitriptan
,
eletriptan
,
frovatriptan
,
naratriptan
,
rizatriptan
,
sumatriptan
,
zolmitriptan
)
-
Tryptamines
(e.g.,
5-BT
,
5-CT
,
5-Et-DMT
,
5-MT
,
5-(nonyloxy)tryptamine
,
DMT
)
|
|
|
|
5-HT
1E
|
|
5-HT
1F
|
|
|
5-HT
2
|
5-HT
2A
|
-
Agonists:
25H/NB series (e.g.,
25I-NBF
,
25I-NBMD
,
25I-NBOH
,
25I-NBOMe
,
25B-NBOMe
,
25C-NBOMe
,
25TFM-NBOMe
,
2CBCB-NBOMe
,
25CN-NBOH
,
2CBFly-NBOMe
)
-
2Cs
(e.g.,
2C-B
,
2C-E
,
2C-I
,
2C-T-2
,
2C-T-7
,
2C-T-21
)
-
2C-B-FLY
-
2CB-Ind
-
5-Methoxytryptamines
(
5-MeO-DET
,
5-MeO-DiPT
,
5-MeO-DMT
,
5-MeO-DPT
,
5-MT
)
-
α-Alkyltryptamines
(e.g.,
5-Cl-αMT
,
5-Fl-αMT
,
5-MeO-αET
,
5-MeO-αMT
,
α-Me-5-HT
,
αET
,
αMT
)
-
AL-34662
-
AL-37350A
-
Bromo-DragonFLY
-
Dimemebfe
-
DMBMPP
-
DOx
(e.g.,
DOB
,
DOC
,
DOI
,
DOM
)
-
Efavirenz
-
Ergolines
(e.g.,
1P-LSD
,
ALD-52
,
bromocriptine
,
cabergoline
,
ergine (LSA)
,
ergometrine (ergonovine)
,
ergotamine
,
lisuride
,
LA-SS-Az
,
LSB
,
LSD
,
LSD-Pip
,
LSH
,
LSP
,
methylergometrine (methylergonovine)
,
pergolide
)
-
Flumexadol
-
IHCH-7113
-
Jimscaline
-
Lorcaserin
-
MDxx
(e.g.,
MDA (tenamfetamine)
,
MDMA (midomafetamine)
,
MDOH
,
MMDA
)
-
O-4310
-
Oxaflozane
-
PHA-57378
-
PNU-22394
-
PNU-181731
-
RH-34
-
SCHEMBL5334361
-
Phenethylamines
(e.g.,
lophophine
,
mescaline
)
-
Piperazines
(e.g.,
BZP
,
quipazine
,
TFMPP
)
-
Serotonin (5-HT)
-
TCB-2
-
TFMFly
-
Tryptamines
(e.g.,
5-BT
,
5-CT
,
bufotenin
,
DET
,
DiPT
,
DMT
,
DPT
,
psilocin
,
psilocybin
,
tryptamine
)
|
-
Antagonists:
5-I-R91150
-
5-MeO-NBpBrT
-
AC-90179
-
Adatanserin
-
Altanserin
-
Antihistamines
(e.g.,
cyproheptadine
,
hydroxyzine
,
ketotifen
,
perlapine
)
-
AMDA
-
Atypical antipsychotics
(e.g.,
amperozide
,
aripiprazole
,
asenapine
,
blonanserin
,
brexpiprazole
,
carpipramine
,
clocapramine
,
clorotepine
,
clozapine
,
fluperlapine
,
gevotroline
,
iloperidone
,
lurasidone
,
melperone
,
mosapramine
,
ocaperidone
,
olanzapine
,
paliperidone
,
quetiapine
,
risperidone
,
sertindole
,
zicronapine
,
ziprasidone
,
zotepine
)
-
Chlorprothixene
-
Cinanserin
-
CSP-2503
-
Deramciclane
-
Dotarizine
-
Eplivanserin
-
Ergolines
(e.g.,
amesergide
,
LY-53857
,
LY-215,840
,
mesulergine
,
metergoline
,
methysergide
,
sergolexole
)
-
Fananserin
-
Flibanserin
-
Glemanserin
-
Irindalone
-
Ketanserin
-
KML-010
-
Landipirdine
-
LY-393558
-
mCPP
-
Medifoxamine
-
Metitepine (methiothepin)
-
MIN-117 (WF-516)
-
Naftidrofuryl
-
Nantenine
-
Nelotanserin
-
Opiranserin (VVZ-149)
-
Pelanserin
-
Phenoxybenzamine
-
Pimavanserin
-
Pirenperone
-
Pizotifen
-
Pruvanserin
-
Rauwolscine
-
Ritanserin
-
Roluperidone
-
S-14671
-
Sarpogrelate
-
Serotonin antagonists and reuptake inhibitors
(e.g.,
etoperidone
,
hydroxynefazodone
,
lubazodone
,
mepiprazole
,
nefazodone
,
triazoledione
,
trazodone
)
-
SR-46349B
-
TGBA01AD
-
Teniloxazine
-
Temanogrel
-
Tetracyclic antidepressants
(e.g.,
amoxapine
,
aptazapine
,
esmirtazapine
,
maprotiline
,
mianserin
,
mirtazapine
)
-
Tricyclic antidepressants
(e.g.,
amitriptyline
)
-
Typical antipsychotics
(e.g.,
chlorpromazine
,
fluphenazine
,
haloperidol
,
loxapine
,
perphenazine
,
pimozide
,
pipamperone
,
prochlorperazine
,
setoperone
,
spiperone
,
spiramide
,
thioridazine
,
thiothixene
,
trifluoperazine
)
-
Volinanserin
-
Xylamidine
-
Yohimbine
|
|
|
5-HT
2B
|
-
Agonists:
4-Methylaminorex
-
Aminorex
-
Amphetamines
(e.g.,
chlorphentermine
,
cloforex
,
dexfenfluramine
,
fenfluramine
,
levofenfluramine
,
norfenfluramine
)
-
BW-723C86
-
DOx
(e.g.,
DOB
,
DOC
,
DOI
,
DOM
)
-
Ergolines
(e.g.,
cabergoline
,
dihydroergocryptine
,
dihydroergotamine
,
ergotamine
,
methylergometrine (methylergonovine)
,
methysergide
,
pergolide
)
-
Lorcaserin
-
MDxx
(e.g.,
MDA (tenamfetamine)
,
MDMA (midomafetamine)
,
MDOH
,
MMDA
)
-
Piperazines
(e.g.,
TFMPP
)
-
PNU-22394
-
Ro60-0175
-
Serotonin (5-HT)
-
Tryptamines
(e.g.,
5-BT
,
5-CT
,
5-MT
,
α-Me-5-HT
,
bufotenin
,
DET
,
DiPT
,
DMT
,
DPT
,
psilocin
,
psilocybin
,
tryptamine
)
|
-
Antagonists:
Agomelatine
-
Atypical antipsychotics
(e.g.,
amisulpride
,
aripiprazole
,
asenapine
,
brexpiprazole
,
cariprazine
,
clozapine
,
N-desalkylquetiapine (norquetiapine)
,
N-desmethylclozapine (norclozapine)
,
olanzapine
,
pipamperone
,
quetiapine
,
risperidone
,
ziprasidone
)
-
Cyproheptadine
-
EGIS-7625
-
Ergolines
(e.g.,
amesergide
,
bromocriptine
,
lisuride
,
LY-53857
,
LY-272015
,
mesulergine
)
-
Ketanserin
-
LY-393558
-
mCPP
-
Metadoxine
-
Metitepine (methiothepin)
-
Pirenperone
-
Pizotifen
-
Propranolol
-
PRX-08066
-
Rauwolscine
-
Ritanserin
-
RS-127445
-
Sarpogrelate
-
SB-200646
-
SB-204741
-
SB-206553
-
SB-215505
-
SB-221284
-
SB-228357
-
SDZ SER-082
-
Tegaserod
-
Tetracyclic antidepressants
(e.g.,
amoxapine
,
mianserin
,
mirtazapine
)
-
Trazodone
-
Typical antipsychotics
(e.g.,
chlorpromazine
)
-
TIK-301
-
Yohimbine
|
|
|
5-HT
2C
|
-
Agonists:
2Cs
(e.g.,
2C-B
,
2C-E
,
2C-I
,
2C-T-2
,
2C-T-7
,
2C-T-21
)
-
5-Methoxytryptamines
(
5-MeO-DET
,
5-MeO-DiPT
,
5-MeO-DMT
,
5-MeO-DPT
,
5-MT
)
-
α-Alkyltryptamines
(e.g.,
5-Cl-αMT
,
5-Fl-αMT
,
5-MeO-αET
,
5-MeO-αMT
,
α-Me-5-HT
,
αET
,
αMT
)
-
A-372159
-
AL-38022A
-
Alstonine
-
CP-809101
-
Dimemebfe
-
DOx
(e.g.,
DOB
,
DOC
,
DOI
,
DOM
)
-
Ergolines
(e.g.,
ALD-52
,
cabergoline
,
dihydroergotamine
,
ergine (LSA)
,
ergotamine
,
lisuride
,
LA-SS-Az
,
LSB
,
LSD
,
LSD-Pip
,
LSH
,
LSP
,
pergolide
)
-
Flumexadol
-
Lorcaserin
-
MDxx
(e.g.,
MDA (tenamfetamine)
,
MDMA (midomafetamine)
,
MDOH
,
MMDA
)
-
MK-212
-
ORG-12962
-
ORG-37684
-
Oxaflozane
-
PHA-57378
-
Phenethylamines
(e.g.,
lophophine
,
mescaline
)
-
Piperazines
(e.g.,
aripiprazole
,
BZP
,
mCPP
,
quipazine
,
TFMPP
)
-
PNU-22394
-
PNU-181731
-
Ro60-0175
-
Ro60-0213
-
Serotonin (5-HT)
-
Tryptamines
(e.g.,
5-BT
,
5-CT
,
bufotenin
,
DET
,
DiPT
,
DMT
,
DPT
,
psilocin
,
psilocybin
,
tryptamine
)
-
Vabicaserin
-
WAY-629
-
WAY-161503
-
YM-348
|
-
Antagonists:
Adatanserin
-
Agomelatine
-
Atypical antipsychotics
(e.g.,
asenapine
,
clorotepine
,
clozapine
,
fluperlapine
,
iloperidone
,
melperone
,
olanzapine
,
paliperidone
,
quetiapine
,
risperidone
,
sertindole
,
ziprasidone
,
zotepine
)
-
Captodiame
-
CEPC
-
Cinanserin
-
Cyproheptadine
-
Deramciclane
-
Desmetramadol
-
Dotarizine
-
Eltoprazine
-
Ergolines
(e.g.,
amesergide
,
bromocriptine
,
LY-53857
,
LY-215,840
,
mesulergine
,
metergoline
,
methysergide
,
sergolexole
)
-
Etoperidone
-
Fluoxetine
-
FR-260010
-
Irindalone
-
Ketanserin
-
Ketotifen
-
Latrepirdine (dimebolin)
-
Medifoxamine
-
Metitepine (methiothepin)
-
Nefazodone
-
Pirenperone
-
Pizotifen
-
Propranolol
-
Ritanserin
-
RS-102221
-
S-14671
-
SB-200646
-
SB-206553
-
SB-221284
-
SB-228357
-
SB-242084
-
SB-243213
-
SDZ SER-082
-
Tedatioxetine
-
Tetracyclic antidepressants
(e.g.,
amoxapine
,
aptazapine
,
esmirtazapine
,
maprotiline
,
mianserin
,
mirtazapine
)
-
TIK-301
-
Tramadol
-
Trazodone
-
Tricyclic antidepressants
(e.g.,
amitriptyline
,
nortriptyline
)
-
Typical antipsychotics
(e.g.,
chlorpromazine
,
loxapine
,
pimozide
,
pipamperone
,
thioridazine
)
-
Xylamidine
|
|
|
|
5-HT
3
–
7
|
5-HT
3
|
-
Agonists:
Alcohols
(e.g.,
butanol
,
ethanol (alcohol)
,
trichloroethanol
)
-
m-CPBG
-
Phenylbiguanide
-
Piperazines
(e.g.,
BZP
,
mCPP
,
quipazine
)
-
RS-56812
-
Serotonin (5-HT)
-
SR-57227
-
SR-57227A
-
Tryptamines
(e.g.,
2-Me-5-HT
,
5-CT
,
bufotenidine (5-HTQ)
)
-
Volatiles/gases
(e.g.,
halothane
,
isoflurane
,
toluene
,
trichloroethane
)
-
YM-31636
|
-
Antagonists:
Alosetron
-
Anpirtoline
-
Arazasetron
-
AS-8112
-
Atypical antipsychotics
(e.g.,
clozapine
,
olanzapine
,
quetiapine
)
-
Azasetron
-
Batanopride
-
Bemesetron (MDL-72222)
-
Bupropion
-
Cilansetron
-
CSP-2503
-
Dazopride
-
Dolasetron
-
Galanolactone
-
Granisetron
-
Hydroxybupropion
-
Lerisetron
-
Memantine
-
Ondansetron
-
Palonosetron
-
Ramosetron
-
Renzapride
-
Ricasetron
-
Tedatioxetine
-
Tetracyclic antidepressants
(e.g.,
amoxapine
,
mianserin
,
mirtazapine
)
-
Thujone
-
Tropanserin
-
Tropisetron
-
Typical antipsychotics
(e.g.,
loxapine
)
-
Volatiles/gases
(e.g.,
nitrous oxide
,
sevoflurane
,
xenon
)
-
Vortioxetine
-
Zacopride
-
Zatosetron
|
|
|
5-HT
4
|
|
5-HT
5A
|
|
5-HT
6
|
-
Agonists:
Ergolines
(e.g.,
dihydroergocryptine
,
dihydroergotamine
,
ergotamine
,
lisuride
,
LSD
,
mesulergine
,
metergoline
,
methysergide
)
-
Hypidone
-
Serotonin (5-HT)
-
Tryptamines
(e.g.,
2-Me-5-HT
,
5-BT
,
5-CT
,
5-MT
,
Bufotenin
,
E-6801
,
E-6837
,
EMD-386088
,
EMDT
,
LY-586713
,
N-Me-5-HT
,
ST-1936
,
tryptamine
)
-
WAY-181187
-
WAY-208466
|
-
Antagonists:
ABT-354
-
Atypical antipsychotics
(e.g.,
aripiprazole
,
asenapine
,
clorotepine
,
clozapine
,
fluperlapine
,
iloperidone
,
olanzapine
,
tiospirone
)
-
AVN-101
-
AVN-211
-
AVN-322
-
AVN-397
-
BGC20-760
-
BVT-5182
-
BVT-74316
-
Cerlapirdine
-
EGIS-12,233
-
GW-742457
-
Idalopirdine
-
Ketanserin
-
Landipirdine
-
Latrepirdine (dimebolin)
-
Masupirdine
-
Metitepine (methiothepin)
-
MS-245
-
PRX-07034
-
Ritanserin
-
Ro 04-6790
-
Ro 63-0563
-
SB-258585
-
SB-271046
-
SB-357134
-
SB-399885
-
SB-742457
-
Tetracyclic antidepressants
(e.g.,
amoxapine
,
mianserin
)
-
Tricyclic antidepressants
(e.g.,
amitriptyline
,
clomipramine
,
doxepin
,
nortriptyline
)
-
Typical antipsychotics
(e.g.,
chlorpromazine
,
loxapine
)
|
|
|
5-HT
7
|
|
-
Antagonists:
Atypical antipsychotics
(e.g.,
amisulpride
,
aripiprazole
,
asenapine
,
brexpiprazole
,
clorotepine
,
clozapine
,
fluperlapine
,
olanzapine
,
risperidone
,
sertindole
,
tiospirone
,
ziprasidone
,
zotepine
)
-
Butaclamol
-
DR-4485
-
EGIS-12,233
-
Ergolines
(e.g.,
2-Br-LSD (BOL-148)
,
amesergide
,
bromocriptine
,
cabergoline
,
dihydroergotamine
,
ergotamine
,
LY-53857
,
LY-215,840
,
mesulergine
,
metergoline
,
methysergide
,
sergolexole
)
-
JNJ-18038683
-
Ketanserin
-
LY-215,840
-
Metitepine (methiothepin)
-
Ritanserin
-
SB-258719
-
SB-258741
-
SB-269970
-
SB-656104
-
SB-656104A
-
SB-691673
-
SLV-313
-
SLV-314
-
Spiperone
-
SSR-181507
-
Tetracyclic antidepressants
(e.g.,
amoxapine
,
maprotiline
,
mianserin
,
mirtazapine
)
-
Tricyclic antidepressants
(e.g.,
amitriptyline
,
clomipramine
,
imipramine
)
-
Typical antipsychotics
(e.g.,
acetophenazine
,
chlorpromazine
,
chlorprothixene
,
fluphenazine
,
loxapine
,
pimozide
)
-
Vortioxetine
|
|
|
|