PHF1
Protein-coding gene in the species Homo sapiens
PHF1 | |||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||
Aliases | PHF1 , MTF2L2, PCL1, PHF2, TDRD19C, hPHD finger protein 1 | ||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM : 602881 MGI : 98647 HomoloGene : 7567 GeneCards : PHF1 | ||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||
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PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene . [5] [6] [7]
Function
This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike . The encoded protein contains a zinc finger -like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene. [7]
References
- 1 2 3 ENSG00000225553, ENSG00000239756 GRCh38: Ensembl release 89: ENSG00000112511, ENSG00000225553, ENSG00000239756 - Ensembl , May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024193 - Ensembl , May 2017
- ↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
- ↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
- ↑ Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics . 48 (3): 381–3. doi : 10.1006/geno.1997.5201 . PMID 9545646 .
- ↑ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell" . Nucleic Acids Research . 36 (9): 2939–47. doi : 10.1093/nar/gkn146 . PMC 2396414 . PMID 18385154 .
- 1 2 "Entrez Gene: PHF1 PHD finger protein 1" .
Further reading
- Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y (March 2008). "Role of hPHF1 in H3K27 methylation and Hox gene silencing" . Molecular and Cellular Biology . 28 (5): 1862–72. doi : 10.1128/MCB.01589-07 . PMC 2258785 . PMID 18086877 .
- O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS (November 2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein" . The Journal of Biological Chemistry . 276 (46): 43065–73. doi : 10.1074/jbc.M104294200 . PMID 11571280 .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi : 10.1016/S0378-1119(97)00411-3 . PMID 9373149 .
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi : 10.1016/0378-1119(94)90802-8 . PMID 8125298 .
External links
- PHF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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