IRX2
Protein-coding gene in the species Homo sapiens
IRX2 | |||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||
Aliases | IRX2 , IRXA2, iroquois homeobox 2 | ||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM : 606198 MGI : 1197526 HomoloGene : 56490 GeneCards : IRX2 | ||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||
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Iroquois-class homeodomain protein IRX-2 , also known as Iroquois homeobox protein 2 , is a protein that in humans is encoded by the IRX2 gene . [5] [6]
Function
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos. [5]
Cancer
IRX2 gene has been observed progressively downregulated in Human papillomavirus -positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. [7] For this reason, IRX2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. [7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000170561 - Ensembl , May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001504 - Ensembl , May 2017
- ↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
- ↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
- 1 2 "Entrez Gene: iroquois homeobox 2" .
- ↑ Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet . 92 (3–4): 320–5. doi : 10.1159/000056921 . PMID 11435706 . S2CID 46509502 .
- 1 2 Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol . 230 (4): 802–812. doi : 10.1002/jcp.24808 . hdl : 11392/2066612 . PMID 25205602 . S2CID 24986454 .
Further reading
- Lam CY, Tam PO, Fan DS, et al. (2008). "A genome-wide scan maps a novel high myopia locus to 5p15" . Invest. Ophthalmol. Vis. Sci . 49 (9): 3768–78. doi : 10.1167/iovs.07-1126 . PMID 18421076 .
- Cirulli ET, Kasperavičiūtė D, Attix DK, et al. (2010). "Common genetic variation and performance on standardized cognitive tests" . European Journal of Human Genetics . 18 (7): 815–20. doi : 10.1038/ejhg.2010.2 . PMC 2987367 . PMID 20125193 .
- Adamowicz M, Radlwimmer B, Rieker RJ, et al. (2006). "Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas". Genes Chromosomes Cancer . 45 (9): 829–38. doi : 10.1002/gcc.20343 . PMID 16752383 . S2CID 24491021 .
- Matsumoto K, Nishihara S, Kamimura M, et al. (2004). "The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation". Nat. Neurosci . 7 (6): 605–12. doi : 10.1038/nn1249 . PMID 15133517 . S2CID 23807922 .
- Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi : 10.1101/gr.6.9.791 . PMID 8889548 .
- Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast" . Cell Tissue Res . 296 (3): 549–54. doi : 10.1007/s004410051316 . PMID 10370142 . S2CID 37046813 .
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode : 2002PNAS...9916899M . doi : 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
This article incorporates text from the United States National Library of Medicine , which is in the public domain .
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