JWH-148
Chemical compound
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Formula | C 24 H 23 N O |
Molar mass | 341.454 g·mol −1 |
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JWH-148 is a synthetic cannabimimetic that was discovered by John W. Huffman . It is the indole 2-methyl analog of JWH-120 . It is a moderately selective ligand for the CB 2 receptor, with a binding affinity of K i = 14.0 ± 1.0 nM at this subtype, and more than eight times selectivity over the CB 1 subtype. [1]
In the United States, all CB 1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-148 are Schedule I Controlled Substances . [2]
See also
References
- ↑ Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, et al. (January 2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists". Bioorganic & Medicinal Chemistry . 13 (1): 89–112. doi : 10.1016/j.bmc.2004.09.050 . PMID 15582455 .
- ↑ 21 U.S.C. § 812 : Schedules of controlled substances
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