Clomegestone acetate
Chemical compound
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Other names | Clomagestone acetate; SH-741; 6-Chloro-17α-acetoxy-16α-methylpregna-4,6-diene-3,20-dione |
Drug class | Progestogen ; Progestogen ester |
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Formula | C 24 H 31 Cl O 4 |
Molar mass | 418.96 g·mol −1 |
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Clomegestone acetate ( USAN ) (developmental code name SH-741 ), or clomagestone acetate , also known as 6-chloro-17α-acetoxy-16α-methylpregna-4,6-diene-3,20-dione , is a steroidal progestin of the 17α-hydroxyprogesterone group which was developed as an oral contraceptive but was never marketed. [1] [2] It is the acetate ester of clomegestone , which, similarly to clomegestone acetate, was never marketed. [1] Clomegestone acetate is also the 17-desoxy cogener of clometherone , and is somewhat more potent in comparison. [3] Similarly to cyproterone acetate , clomegestone acetate has been found to alter insulin receptor concentrations in adipose tissue, and this may indicate the presence of glucocorticoid activity. [4] [5]
References
- 1 2 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. pp. 297–. ISBN 978-1-4757-2085-3 .
- ↑ Lawrence MM (1971). CENTO Workshop Series on Clinical and Applied Research in Family Planning, Ankara, Turkey, February 23-26: Tehran, Iran, March 1-4; Lahore, Pakistan, March 9-12, 1971; [ papers . Central Treaty Organization.
- ↑ Lednicer D (20 June 2011). Steroid Chemistry at a Glance . John Wiley & Sons. pp. 5–. ISBN 978-1-119-95729-4 .
- ↑ Krauth MC, Schillinger E (November 1977). "Changes in insulin receptor concentration in rat fat cells following treatment with the gestagens clomegestone acetate and cyproterone acetate". Acta Endocrinologica . 86 (3): 667–72. doi : 10.1530/acta.0.0860667 . PMID 579029 .
- ↑ Schillinger E, Gerloff C, Gerhards E, Günzel P (February 1974). "Glucose tolerance and serum insulin in rats and insulin sensitivity of rat adipose cells following treatment with the progestogen clomegestone acetate". Acta Endocrinologica . 75 (2): 305–13. doi : 10.1530/acta.0.0750305 . PMID 4406547 .
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