Clogestone acetate
Chemical compound
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Other names | Chlormadinol acetate; AY-11440; 3β,17α-Diacetoxy-6-chloropregna-4,6-diene-20-one |
Drug class | Progestogen ; Progestogen ester |
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Formula | C 25 H 33 Cl O 5 |
Molar mass | 448.98 g·mol −1 |
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Clogestone acetate ( USAN ) (developmental code name AY-11440 ), also known as chlormadinol acetate or as 3β,17α-diacetoxy-6-chloropregna-4,6-diene-20-one , [1] is a steroidal progestin which was investigated as a progestin-only contraceptive and postcoital contraceptive but was never marketed. [2] [3] [4] [5] It is the di acetate ester of clogestone , which, similarly was never marketed. [2] Clogestone acetate produces chlormadinone acetate as an active metabolite . [6]
See also
References
- ↑ Litwack G (2 December 2012). Biochemical Actions of Hormones . Elsevier. pp. 323–. ISBN 978-0-323-15189-4 .
- 1 2 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. pp. 297–. ISBN 978-1-4757-2085-3 .
- ↑ Hawkins DR, Elder MG (22 October 2013). Human Fertility Control: Theory and Practice . Elsevier Science. pp. 3–. ISBN 978-1-4831-6361-1 .
- ↑ Harper MJ (8 March 2013). "Contraception--retrospect and prospect" . Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progres Des Recherches Pharmaceutiques . Birkhäuser. 21 : 293–407. ISBN 978-3-0348-7098-6 . PMID 339271 .
- ↑ Hinselmann M, Jürgensen O, Hasselblatt I, Otten U, Prinz W, Taubert HD (August 1970). "[Clogestone acetate, a new orally effective progestagen]". Archiv Fur Gynakologie (in German). 209 (2): 136–148. doi : 10.1007/BF00668180 . PMID 5537778 .
- ↑ Stern MD, Givner ML (April 1975). "Measurement of serum clogestone acetate (AY-11,440) by a radioreceptor assay: a practical approach to the quantitative determination of synthetic progestins". The Journal of Clinical Endocrinology and Metabolism . 40 (4): 728–731. doi : 10.1210/jcem-40-4-728 . PMID 1127082 .
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