Adenosine diphosphate ribose
Chemical compound
Names | |
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Other names
ADP ribose
ADPR Adenosine 5'-diphosphoribose |
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Identifiers | |
3D model (
JSmol
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ChEMBL | |
ChemSpider |
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MeSH | Adenosine+Diphosphate+Ribose |
PubChem
CID
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UNII | |
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Properties | |
C 15 H 23 N 5 O 14 P 2 | |
Molar mass | 559.316 g/mol |
Except where otherwise noted, data are given for materials in their
standard state
(at 25
°C [77
°F], 100
kPa).
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Adenosine diphosphate ribose ( ADPR ) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase . [1] ADPR is created from cyclic ADP-ribose (cADPR) by the CD38 enzyme using nicotinamide adenine dinucleotide (NAD + ) as a cofactor . [1]
ADPR binds to and activates the TRPM2 ion channel. [2] ADPR is the most potent agonist of the TRPM2 channel. [3] cADPR also binds to TPRM2, and the action of both molecules is synergistic , with both molecules enhancing the action of the other molecule in activating the TRPM2 channel. [4]
See also
References
- 1 2 Braidy N, Berg J, Clement J, Sachdev P (2019). "Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes" . Antioxidants & Redox Signaling . 10 (2): 251–294. doi : 10.1089/ars.2017.7269 . PMC 6277084 . PMID 29634344 .
- ↑ Fonfria E, Marshall IC, Benham CD, et al. (September 2004). "TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase" . Br. J. Pharmacol . 143 (1): 186–92. doi : 10.1038/sj.bjp.0705914 . PMC 1575275 . PMID 15302683 .
- ↑ Yu P, Cai X, Liang Y, Yang W (2019). "Roles of NAD + and Its Metabolites Regulated Calcium Channels in Cancer" . Molecules . 25 (20): 4826. doi : 10.3390/molecules25204826 . PMC 7587972 . PMID 33092205 .
- ↑ Lee HC (2011). "Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling" . Science China Life Sciences . 54 (8): 699–711. doi : 10.1007/s11427-011-4197-3 . PMID 21786193 . S2CID 24286381 .
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