PD-0298029
Chemical compound
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Chemical and physical data | |
Formula | C 27 H 32 N 2 O 4 |
Molar mass | 448.563 g·mol −1 |
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PD-0298029 is a drug which acts as a selective antagonist for the muscarinic acetylcholine receptor M 4 . It was developed for the treatment of Parkinson's disease , but poor bioavailability and rapid metabolism in animal studies have meant its use is largely limited to in vitro research into the M 4 and other muscarinic receptors. [1] [2] [3]
See also
References
- ↑ Böhme TM, Augelli-Szafran CE, Hallak H, Pugsley T, Serpa K, Schwarz RD (July 2002). "Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors". Journal of Medicinal Chemistry . 45 (14): 3094–102. doi : 10.1021/jm011116o . PMID 12086495 .
- ↑ Boehme TM, Angelli-Szafran CE, Corinne E, Hallak H and Schwarz RD. Analogs of M4 selective synthetic muscarinic receptor antagonists: Synthesis, binding and pharmacokinetic properties. Medicinal Chemistry Research . 2002; 11(8):423–433.
- ↑ Progress in Medicinal Chemistry 43. (2005). Chapter 4, Muscarinic Receptor Subtype Pharmacology and Physiology, by Richard M Eglen. pp 128-129. ISBN 0-444-51572-0
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