Heck's disease
Medical condition
Heck ' s disease | |
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Other names | Multifocal epithelial hyperplasia |
Specialty | Oral and maxillofacial surgery |
Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the oral cavity. [1] [2] : 411 Can present with slightly pale, smooth or roughened surface morphology. It is caused by the human papilloma virus types 13 and 32. [3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies. It shows 'cobblestone' appearance clinically. It was first identified in the Aboriginal population of North America. [4]
Over time, they will spontaneously regress without treatment. [5] Possible treatment may be excisional biopsy for lesions of functional or aesthetic concern. [ citation needed ]
References
- ↑ Tenore, G.; Palaia, G.; Del Vecchio, A.; Galanakis, A.; Romeo, U. (2013-10-24). "Focal epithelial hyperplasia (Heck's disease)" . Annali di Stomatologia . 4 (Suppl 2): 43. ISSN 1824-0852 . PMC 3860189 . PMID 24353818 .
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology . Saunders Elsevier. ISBN 0-7216-2921-0 .
- ↑ James, William D.; Berger, Timothy; Elston, Dirk (2015). Andrews' Diseases of the Skin E-Book: Clinical Dermatology . Elsevier Health Sciences. p. 408. ISBN 9780323319690 .
- ↑ Archard, Howell O; Heck, John W; Stanley, Harold R (1965). "Focal epithelial hyperplasia: An unusual oral mucosal lesion found in Indian children". Oral Surgery, Oral Medicine, Oral Pathology . 20 (2): 201–12. doi : 10.1016/0030-4220(65)90192-1 . PMID 14322615 .
- ↑ Eversole, Lewis R. (2011). Clinical Outline of Oral Pathology: Diagnosis and Treatment . PMPH-USA. p. 285. ISBN 9781607950158 . Retrieved 18 January 2018 .
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